A Paradigm Shift of Genome Biology: From Macrobiosphere to Microbiosphere

Jun Yu (于军)

Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
Email: junyu@big.ac.cn

Jun Yu (September, 2018) is currently a CAS-Endowed Professor at Beijing Institute of Genomics, Chinese Academy of Sciences. Yu obtained PhD degree in Biomedical Sciences from New York University Medical School (1990) and BS in Biochemistry from Jilin University (1983). Yu's research activities are largely focused on genomics, bioinformatics, and large-scale sequencing instrumentation, and has published over 300 peer-reviewed journal articles. Among academic awards and honors he has received are: TWAS Prize in Agricultural Sciences (2012), CAS Outstanding Science and Technology Achievements (2003), "Qiushi" Annual Award for Scientific Achievement (2002), CAS 100-Person Plan, (2002), NSF Outstanding Young Investigator Award (for oversea scholars, 1999), American Foundation for Urological Diseases PhD Research Scholar (1991), and China-US Biology Examination and Application (CUSBEA) Scholarship for Ph.D. Candidate (1983). He has been Editor-in-Chief for Genomics, Proteomics, and Bioinformatics since 2003.

Two-dimensional membranes: physics and biomedical applications

Marija Drndic

University of Pennsylvania,

Marija Drndic is the Fay R. and Eugene L. Langberg Professor in the Department of Physics and Astronomy at the University of Pennsylvania. She received her MPhil from Cambridge University, AB, AM and PhD from Harvard University, all in Physics, and was a Pappalardo Fellow at Massachusetts Institute of Technology, before joining Penn in 2003. Her work on cold atom manipulation, nanocrystal electronics and nanofabrication was recognized by the Presidential Young Investigator Award, the Alfred Sloan Fellowship, the DARPA Young Faculty Award, the ONR Young Investigator, and the NSF Career Award. In 2013 she was named the APS Fellow "for development of novel nanofabrication methods for graphene nanoelectronics and fast biomolecular analysis in solution". She also received several teaching awards, including the Edmund J. and Louise W. Kahn Award for Distinguished Teaching. The research in Drndic lab focuses on the exploration of nanoscale structures in the areas of experimental condensed matter physics, nanoscience and nanotechnology. The group is known for their studies of fundamental physical properties of low-dimensional and small-scale structures and the development of their device applications.

A new framework of phylogenetic studies: human origins and hepatitis B virus evolution

Shi Huang (黄石)

Center for Medical Genetics School of Life Sciences Xiangya Medical School Central South University, 110 Xiangya road, Changsha, Hunan, China 410078

Dr. HUANG Shi was a professor at the Center for Medical Genetics at Central South University in Changsha, China. He entered Fudan University in 1979 and graduated in 1983 with a bachelor's degree in genetics. He was a CUSBEA fellow of Class III (1984) and obtained his Ph.D. in biochemistry at the University of California at Davis in 1988. After finishing a postdoctoral training at the University of California at San Diego, he was on the faculty at the Sanford-Burnham Institute in San Diego California from 1992 to2008. He was appointed professor at Central South University in 2009. He was one of the 1993 class of Pew Scholars in the Biomedical Sciences and a 2010 Furong Scholar. His laboratory discovered the RIZ or PRDM family of histone methyltransferases and proposed an epigenetic pathway of carcinogenesis by diet rich in meat and low in vegetables. Since 2003, he initiated study of the relationship between genetics and epigenetics and its role in the evolution of biological complexity. He proposed the maximum genetic diversity hypothesis and has been using it to rewrite evolution and population genetics as well as to solve genetic puzzles of complex traits/diseases. In 2017, he proposed the Out of Asia model for modern humans.

Ecology-based data mining for metagenomics of human gut microbiome in metabolic diseases

Liping Zhao (赵立平)

Rutgers University,The State University of New Jersey,NJ,USA Shanghai Jiao Tong University, Shanghai,China

Liping Zhao is currently the Eveleigh-Fenton Chair of Applied Microbiology at Rutgers University and Distinguished Professor of Microbiology at Shanghai Jiao Tong University. He is a senior editor of the ISME Journal and associate editor of the journal Microbiome. He is a fellow of American Academy of Microbiology. He is a senior fellow of Canadian Institute for Advanced Research (CIFAR). He serves on Scientific Advisory Board for Center for Microbiome Research and Education of American Gastroenterology Association (AGA). His team has pioneered the approach of applying metagenomics-metabolomics integrated tools and dietary intervention for systems understanding and predictive manipulation of gut microbiota to improve human metabolic health. Following the logic of Koch's postulates, Liping has found that an endotoxin-producing opportunistic pathogen isolated from an obese human gut can induce obesity in germfree mice. Their clinical trials published in Science and EBioMedicine showed that dietary modulation of gut microbiota can significantly alleviate metabolic diseases including a genetic form of obesity in children and type 2 diabetes in adults. The Science magazine featured a story on how he combines traditional Chinese medicine and gut microbiota study to understand and fight obesity (Science 336: 1248).

The opium poppy genome and morphinan production

Kai Ye (叶凯)

Xi'an Jiaotong University, Xi'an, Shanxi, 710069 P.R.China
E-mail: kaiye@xjtu.edu.cn,

Professor Kai Ye obtained his PhD from Leiden University, the Netherlands, in 2008. He spent one year in European Bioinformatics Institute as postdoc and shifted research interest from protein to genome. After three years as an assistant professor at Leiden University Medical Center, working longevity and aging, he went to Washington University in St. Louis as an assistant professor, investigating novel computational methods for cancer research. He returned to China in the beginning of 2016 as a full professor at Xi'an Jiaotong University. Since 2008, professor Kai Ye has developed multiple next-generation sequence analysis algorithms, being used as the standard module in the 1000 Genomes Project, the Cancer Genome Atlas, the International Cancer Genome Project, the Genome of the Netherlands. Professor Ye has published more than 50 papers, including 10 on Nature, as well as in high impact journals such as PNAS, Nature Genetics, Nature Methods, Nature Medicine, Nature Communications and Genome Research. His citation is more than 10k according ESI database. With the support from 1000 Talents Plan and several national precision medicine related grants, professor Ye is leading an inter-disciplinary team to tackle challenging questions in biomedical research using both informatics and biological systems.

TMachine learning for the knowledge mining from high-throughput proteomic datasets at the era of big data

Dong Li(李栋)

State Key Lab of Proteomics, Beijing Institute of Life Omics
Email: lidong.bprc@foxmail.com

Dong Li is a professor from State Key Lab of Proteomics, Beijing Institute of Life Omics. And now he is the director of the biological big data department. Dong Li has been engaged in the bioinformatics study in proteomic field for 12 years since he got his PHP from Peking University in 2006. Dong Li is interested in the research of topology structure, biological function, evolution and dynamics of large-scale biological networks. He has developed multiple bioinformatics web services such as GOfact, PRINCESS,SLIPPER, Batman-TCM and UbiBrowser, which have gained over 50,000 visits. And now he is leading his team to establish the knowledge-mining portal to integrate multiple biological big data (genome, transcriptome and proteome) to generate hypothesis for biological mechanism, disease diagnosis and drug development. Dong Li is the current member of the editorial board of Proteomics and Frontiers of pharmacology, and he has published 21 peer-reviewed research papers in Nature communications, Molecular&Cellular Proteomics, Molecular Systems Biology etc.